Nucleosome knowledge base (beta)

Licence and attributions

Licence

This site, the notation engine, and the build scripts are released under the MIT License. Authored data, including the registry, the vocabulary, the curated literature store and the measurement containers are released under CC BY 4.0.

Copyright © 2026 Benjamin Buchmuller

Feedback:

The notation follows Keogh et al., “A Needed Nomenclature for Nucleosomes” (Molecular Cell, 2025) — PMC12778995.

Third-party data are redistributed on their own terms, listed below.

Data sources in the tables

18 sources are ingested into the measurement tables. A further 3 containers carry invented numbers for design work; every row from them is badged mock wherever it appears, and none is attributed to any paper.

AlphaMissense (Cheng et al., 2023, Science)
9606_alphamissense
ACF · Remodeling
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID28767641-ACF
CHD4 · Remodeling
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID28767641-CHD4
CHRAC · Remodeling
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID28767641-CHRAC
NoRC · Remodeling
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID28767641-NoRC
NURF · Remodeling
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID28767641-NURF
RSF · Remodeling
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID28767641-RSF
SNF2h · Remodeling
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID28767641-SNF2h
WICH · Remodeling
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID28767641-WICH
ACF · Remodeling
Oncohistone mutations enhance chromatin remodeling and alter cell fates
Bagert JD, Mitchener MM … Allis CD, Muir TW
Nat Chem Biol · 2021 · PMID 33649601 · PMID33649601-ACF
Nap1 · Dimer exchange
Oncohistone mutations enhance chromatin remodeling and alter cell fates
Bagert JD, Mitchener MM … Allis CD, Muir TW
Nat Chem Biol · 2021 · PMID 33649601 · PMID33649601-Nap1
ATPase · Remodeling
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
Mashtalir N, Dao HT … Muir TW, Kadoch C
Science · 2021 · PMID 34437148 · PMID34437148-ATPase
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID34437148-ATPase
cBAF_1 · Remodeling
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
Mashtalir N, Dao HT … Muir TW, Kadoch C
Science · 2021 · PMID 34437148 · PMID34437148-cBAF_1
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID34437148-cBAF_1
cBAF · Remodeling
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
Mashtalir N, Dao HT … Muir TW, Kadoch C
Science · 2021 · PMID 34437148 · PMID34437148-cBAF_2
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID34437148-cBAF_2
ncBAF · Remodeling
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
Mashtalir N, Dao HT … Muir TW, Kadoch C
Science · 2021 · PMID 34437148 · PMID34437148-ncBAF
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID34437148-ncBAF
PBAF · Remodeling
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
Mashtalir N, Dao HT … Muir TW, Kadoch C
Science · 2021 · PMID 34437148 · PMID34437148-PBAF
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID34437148-PBAF
SMARCA4_FL · Remodeling
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
Mashtalir N, Dao HT … Muir TW, Kadoch C
Science · 2021 · PMID 34437148 · PMID34437148-SMARCA4_FL
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID34437148-SMARCA4_FL
TG2 · Monoaminylation
TGM2-mediated histone transglutamination is dictated by steric accessibility
Lukasak BJ, Mitchener MM … Maze I, Muir TW
Proc Natl Acad Sci U S A · 2022 · PMID 36256821 · PMID36256821-TG2
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
Dann GP, Liszczak GP … Allis CD, Muir TW
Nature · 2017 · PMID 28767641 · PMID36256821-TG2
PRC1 · H2A ubiquitylation mock

Effect sizes here are invented. The biology being imitated (PRC1/RING1B ubiquitylates H2A at K119; H3.3 K27M is the paediatric-glioma oncohistone) is real, but no number in this container came from an experiment and none is attributed to any investigator or paper.

MOCK-10090-PRC1
Bre1/Rad6 · H2B ubiquitylation mock

Effect sizes here are invented. The biology being imitated (Bre1/Rad6 ubiquitylates budding-yeast H2B at K123, the residue equivalent to human H2B K120) is real and well established, but no number in this container came from an experiment and none is attributed to any investigator or paper.

MOCK-4932-H2Bub
Array compaction · Array compaction mock

Effect sizes here are invented. The biology being imitated (H4 K16 acetylation opposes compaction of reconstituted nucleosome arrays) is real and well established, but no number in this container came from an experiment and none is attributed to any investigator or paper.

MOCK-8355-arrayfold

Reference datasets

AlphaMissense CC BY-NC-SA 4.0

Predicted pathogenicity of missense substitution in the human proteome

Cheng J. et al. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense. Science 381, eadg7492. doi:10.1126/science.adg7492

Non-commercial use only; derivatives carry the same licence.

https://zenodo.org/records/8208688

UniProt CC BY 4.0

Protein sequences and initiator-methionine annotations

https://www.uniprot.org

HistoneDB 2.0 Public domain (NCBI)

Histone family and variant classification

Draizen E.J. et al. (2016). HistoneDB 2.0. Database 2016, baw014.

https://www.ncbi.nlm.nih.gov/research/histonedb/

Ensembl Apache 2.0

Gene locus counts

https://www.ensembl.org

PubMed Public domain (NLM)

Literature index (titles, authors, journals, MeSH terms); abstract text is not redistributed

https://pubmed.ncbi.nlm.nih.gov

Software

DuckDB-WASM MIT

In-browser SQL engine loaded from jsDelivr at run time, not bundled

https://github.com/duckdb/duckdb-wasm

Jekyll MIT

Static site generator

https://jekyllrb.com

peggy MIT

Notation grammar compilation at build time

https://peggyjs.org

Fonts

TeX Gyre Heros, Pagella and Cursor GUST Font License

Sans, serif and monospace font faces. Copyright GUST, the Polish TeX Users Group.

Restricted to unicode-range subsets. The subsets are not the original fonts and do not claim to be.

https://www.gust.org.pl/projects/e-foundry/tex-gyre

Font APEX SIL Open Font License 1.1

Icon font. Copyright Oracle and/or its affiliates.

https://github.com/oracle/font-apex

This page is generated at build time from the containers under data/ and from docs/_data/third_party.yml. Engine build 58e7a9fb9db9.